Laboratory findings(2) Additional measurement: IGF-1, IGFBP-3 tSH, T4, ACTH, LHRH X ray: Skeletal maturation show bone age is delayed. Image examination: Skull study by X ray, Ct or mri to observe the calcification. erosion within or above the sella etcLaboratory findings (2) • Additional measurement: IGF-1 ， IGFBP-3, TSH，T4，ACTH，LHRH. • X ray : Skeletal maturation show bone age is delayed. • Image examination：Skull study by X ray, CT or MRI to observe the calcification, erosion within or above the sella etc