Etiology pathogenesis Viral infection( Coxsackie EBV, measles, mumps Milk proteins (lactoalbumin, 1 Environment - casein,β- casein, lactoglobulin Cow insulin Chemical agents AutoantigenS: GadIA-2, InsulinEtiology & pathogenesis Viral infection（Coxsackie， EBV，measles，mumps） Milk proteins (lactoalbumin, －casein, - casein, lactoglobulin) Cow insulin Autoantigens: GAD，IA-2，Insulin Environment Chemical agents .Autoimmune 1