安徽医科大学国际教育学院教案 Teaching Plan for International Students,AHMU Title of the course:Physiological and laboratory markers of drug effect Chapter:_ 17 Teacher's name: Dr.Qingtong Wang Grade: 2013 Department:School of International Education Time:14:30-16:50 Date(D/M/Y):3/23/2016 Teaching 1.Master the concept of biomarker,clinical endpoints,and surrogate endpoint Objectives; 2.Recognize the function of biomarkers in drug efficacy toxicity Teaching 3.Recognize the use of biomarkers in drug development Requirements 4.Know the future development of biomarkers Teaching 1.Biological markers of drug effect Content 2.Biological markers in drug development 3.Future development of biomarkers Teaching Teaching Focus:The use of biomarkers in evaluating drug effects,toxicity Focus; and drug development. Difficult Difficult Problems:the concept and difference of biomarker,clinical endpoints,and surrogate endpoint.How the biomarker acts in the clinical Problems practice and their Solutions:Give examples of clinical drug use(the effect and toxicity events) Solutions and the use of biomarker.Compare the three words indetail. 1.The concept of biomarker,clinical endpoints,and surrogate endpoint 8min Time 2.Biological markers of drug effect 14min Allotment 3.Biological markers in drug development 10min 4.Future development of biomarkers 8min 1. The definition of Biomarker,Clinical Endpoint,Surrogate Endpoint, Assignment Intermediate Endpoint,Ultimate Outcome.Give examples. 2.The use of Biomarkers in drug development and clinical practice. 1.Principle of Clinical Pharmacology(Second Edition);ArthurJ.Atkinson Reference 2.Basic Clinical Pharmacology;Bertram G Katzung Text 3.Oxford Textbook of Clinical Pharmacology and Drug Therapy;David Grahame-Smith,Jeffrey Aronson Memo 1安徽医科大学国际教育学院教案 1 Teaching Plan for International Students, AHMU Title of the course: Physiological and laboratory markers of drug effect Chapter: 17 Teacher’s name: Dr. Qingtong Wang Grade: 2013 Department: School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/23/2016 Teaching Objectives; Teaching Requirements 1. Master the concept of biomarker, clinical endpoints, and surrogate endpoint 2. Recognize the function of biomarkers in drug efficacy & toxicity 3. Recognize the use of biomarkers in drug development 4. Know the future development of biomarkers Teaching Content 1. Biological markers of drug effect 2. Biological markers in drug development 3. Future development of biomarkers Teaching Focus; Difficult Problems and their Solutions Teaching Focus: The use of biomarkers in evaluating drug effects, toxicity and drug development. Difficult Problems: the concept and difference of biomarker, clinical endpoints, and surrogate endpoint. How the biomarker acts in the clinical practice Solutions: Give examples of clinical drug use (the effect and toxicity events) and the use of biomarker. Compare the three words indetail. Time Allotment 1. The concept of biomarker, clinical endpoints, and surrogate endpoint 8min 2. Biological markers of drug effect 14min 3. Biological markers in drug development 10min 4. Future development of biomarkers 8min Assignment 1. The definition of Biomarker, Clinical Endpoint, Surrogate Endpoint, Intermediate Endpoint, Ultimate Outcome. Give examples. 2. The use of Biomarkers in drug development and clinical practice. Reference Text 1. Principle of Clinical Pharmacology (Second Edition); ArthurJ. Atkinson 2. Basic & Clinical Pharmacology; Bertram G. Katzung 3.Oxford Textbook of Clinical Pharmacology and Drug Therapy; David Grahame-Smith, Jeffrey Aronson Memo