Antibiotics Inhibit Protein Synthesis inhibitors of initation .30S Ribosomal Subunit(Aminoglycosides Tetracyclines, Spectinomycin) .50S Ribosomal Subunit(Chloramphenicol, Macrolides) nhibitors of elongation .Elongation Factor G Fusidic acid) Mostly bacteriostatic Selectivity due to differences in prokaryotic and eukaryotic ribosomes Some toxicity -70S ribosomes eukaryotic in mitochondriaAntibiotics Inhibit Protein Synthesis •Inhibitors of INITATION •30S Ribosomal Subunit (Aminoglycosides, Tetracyclines, Spectinomycin) •50S Ribosomal Subunit (Chloramphenicol, Macrolides) •Inhibitors of ELONGATION •Elongation Factor G (Fusidic acid) Mostly bacteriostatic Selectivity due to differences in prokaryotic and eukaryotic ribosomes Some toxicity - 70S ribosomes eukaryotic in mitochondria