T and B cells Both T and B cells are involved in the immune response and under the light microscope can not be distinguished.Surface markers are used to distinguish T and B cells. Bone Marro 1steiet 3sophl 60 Eosinophil Macrophages T&BLymphocute T and B cells Both T and B cells are involved in the immune response and under the light microscope can not be distinguished. Surface markers are used to distinguish T and B cells