Learning Objectives 1. To review the normal structure-function relationships of Hb and expression of globin g enes 2. To examine the hemoglobinopathies as disorders of Hb structure, or a-or B-globin gene expression 3. To explore the influences of compound heterozygosity and modifier genes on hemoglobinopathy phenotypesLearning Objectives 1. To review the normal structure-function relationships of Hb and expression of globin genes 2. To examine the hemoglobinopathies as disorders of Hb structure, or α- or β-globin gene expression 3. To explore the influences of compound heterozygosity and modifier genes on hemoglobinopathy phenotypes