2) Catecholamine(CA) Effective circulating blood flowl or toxin 3) excitation of sympathetic-adrenomedullary system CA↑→ vasoconstriction of renal cortex 4) especially of afferent arteriole Renal diseases may stimulate blood vessel ec to secrete et 5) During ArF the level of plasma et and the ability of eTr to combine et are all increased, which will directly or indirectly lead to renal vasoconstriction ICpc uson nJuypiollote llv All these go into a vicious circle and cause increasingly severe damage 2727 2) Catecholamine (CA) 3) Prostaglandins (PG) 4) Endothelin (ET) 5) Others: NO synthesis↓, ADH, PAF and TNF↑and ischemia￾reperfusion injury → promote ATN Renal diseases may stimulate blood vessel EC to secrete ET. During ARF the level of plasma ET and the ability of ET-R to combine ET are all increased, which will directly or indirectly lead to renal vasoconstriction All these go into a vicious circle and cause increasingly severe damage Decreased synthesis of PG → PGI2 /TXA2 ↓ → renal vasoconstriction Effective circulating blood flow↓ or toxin → excitation of sympathetic-adrenomedullary system → CA↑→vasoconstriction of renal cortex especially of afferent arteriole