Activators Human Transcription These regulatory proteins bind to DNA at distant sites known as enhancers. when Complex DNA folds so that the enhancer is brought into proximity with the transcription complex, Repressors the activator proteins interact with the complex These regulatory proteins bind to"silencer to increase the rate of transcription sites on the DNA, preventing the binding of activators to nearby enhancers and so Silencer slowing transcription Enhancer. Repressor Basal factors These transcription factors, in Activator response to coactivators, position RNA Enhancer. polymerase at the start of a protein- coding sequence, and then release the Enhancer olymerase to transcribe the mrNA Activator Activator 250 DNA 40 110 60 150 80 RNA polymerase TATA binding f Coding region tei Coactivators TATA box Core These transcription factors promoter transmit signals from activator proteins to the basal factors. 2005-11-11 Chaoqun Wu, Fudan University2005-11-11 Chaoqun Wu, Fudan University Chaoqun Wu, Fudan University 11