Organic Chemistry Organic and Biological Chemistry in Modern Medicine Coronary artery disease(CAD)is directly correlated with blood cholesterol levels冠状动脉疾病 75%of blood cholesterol (1000 mg a day)is biosynthesized -Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels他汀类药物 他汀类降血脂药) 3-Hydroxy-3-methylglutaryl coenzyme A(HMG-CoA)to mevalonate conversion 3-羟基-3甲基戊二酰辅酶A Crucial step in biosynthesis of cholesterol Atorvastatin (Lipitor)inactivates enzyme that catalyzes HMG-CoA to mevalonate conversion ■阿托伐他汀Organic and Biological Chemistry in Modern Medicine Coronary artery disease (CAD) is directly correlated with blood cholesterol levels  75% of blood cholesterol (1000 mg a day) is biosynthesized Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate conversion Crucial step in biosynthesis of cholesterol Atorvastatin (Lipitor) inactivates enzyme that catalyzes HMG-CoA to mevalonate conversion 阿托伐他汀 Organic Chemistry 冠状动脉疾病 他汀类药物 3-羟基-3甲基戊二酰辅酶A 他汀类降血脂药）