Etiologies of PUo a Bacterial Endocarditis a Culture remains negative in 5% of patient a Culture negative is likely with the following organisms. 口 Coxiella burnetii→ no growth 口 HACEK group→ incubate blood7-21days 口 Brucella 3 Special media/ 口 Legionella 3 long time 口 Mycoplasm/Chlamydia} 口 Funga→ usually sterile a Peripheral signs may not be detected Right-side Endocarditis→ Lack murmurs→self antibiotics ->growth(-ve)Etiologies of PUO Bacterial Endocarditis  Culture remains negative in 5% of patient.  Culture negative is likely with the following organisms:  Coxiella burnetii → no growth.  HACEK group → incubate blood 7 – 21 days  Brucella } Special media/  Legionella } long time  Mycoplasm/Chlamydia }  Fungal → usually sterile  Peripheral signs may not be detected.  Right-side Endocarditis → Lack murmurs → self antibiotics → growth (-ve)