L4: Cooperativity introduction 2 phage model n phage model (Hasty et al.) as example for applying mass action law K 2Ⅹ K D+Ⅹ.<2>Dx most important K fast step in OR2 OR3 modeling D+X DX K Dx,+2 DxDⅩ OR3 DX+P DX+P+nⅩ most im portant A Slow step in modeling ! biology mathL4: Cooperativity & introduction λ phage model λ phage model (Hasty et al.) as example for applying mass action law. A dk X P nX 2 DX tk P 2 DX 2 DX 2 DX 4K 2X 2 DX * 2 DX 3K 2 D X 2 DX 2K 2 D X 2X 1K 2X ⎯⎯ →⎯ + ⎯⎯ →⎯ + + + ←⎯ →⎯ + ←⎯ →⎯ + ←⎯ →⎯ ←⎯ →⎯ OR2 OR3 λ λ λ λ λ λ OR2 OR3 λ λ OR2 OR3 λ λ λ λ K1 K2 fast slow most important step in modeling !! most important step in modeling !! biology math