Live Heat-killed Live Live R cells Live S cells S cells R cells heat-killed S cells S cells 2012 Pearson Education,Inc Griffith's experiments with pneumococcus. Live smooth(S)cells contain a capsule and kill mice. Rough(R)cells have no capsule and are not pathogenic. But a combination of live R and dead S cells kill mice,and live S type cells can be isolated from the animals.Griffith's experiments with pneumococcus. • Live smooth (S) cells contain a capsule and kill mice. • Rough (R) cells have no capsule and are not pathogenic. • But a combination of live R and dead S cells kill mice, and live S type cells can be isolated from the animals