Medical Genetics 1. REGRESSION TO THE MEAN Multifactorial inheritance was first studied by Galton a close relative of darwin and a contemporary of Mendel. Galton established the principle of what he termed regression to mediocrityMedical Genetics 1. REGRESSION TO THE MEAN Multifactorial inheritance was first studied by Galton, a close relative of Darwin and a contemporary of Mendel. Galton established the principle of what he termed "regression to mediocrity