Epidemiology Incidence consistent worldwide 1% general population - Hereditary trend 10%siblings, parents /offspring dizygotic twins 50% monozygotic twins Environmental factors implicated Prenatal stress-infection, famine, war, death of spouse Season of birth -winter> summer -Cannabis --Urban setting >rural setting ge of onset -Men17-27, Women17-37 -Childhood onset extremely rare: 1 in 10,000-100,000 Outcome 10% good-optimistic 80% remission without full recovery 10% no remissionEpidemiology • Incidence consistent worldwide --1% general population --Hereditary trend: 10% siblings , parents / offspring, dizygotic twins 50% monozygotic twins • Environmental factors implicated --Prenatal stress - infection, famine, war, death of spouse --Season of birth - winter > summer --Cannabis --Urban setting > rural setting • Age of onset --Men 17 - 27, Women 17 - 37 --Childhood onset extremely rare: 1 in 10,000-100,000 • Outcome --10% good - optimistic --80% remission without full recovery --10% no remission 6