R10 肽的固相合成H0N80+C2 树脂」 CH CH3 RiO Hc-0—N-g--O-c 树脂 CH3 HCI-HAc R10 Hc→+C2+HN-gOc 树脂 DCC,BOC-氨基酸2 H3 R20 R10 Hc 树脂 CH3 HBr-F3CCOOH CH2 R2 O R10 H C-+C0,+HN O一N一C OH+Br一 树脂 CH3H3 C CH3 CH3 O O N H C H R1 O O C H2 Cl H3 C CH3 CH3 O O N H C H R1 O O C H2 H3 C CH2 CH3 H2 N C H R1 O O C H2 H3 C CH3 CH3 O O N H C H R2 O O N H C H R1 O O C H2 H3 C CH2 CH3 C H2 H N Br 2 C H R2 O O N H C H R1 O OH + 树 脂 树 脂 + CO2+ 树 脂 树 脂 + CO2+ + 树 脂 HCl－HAc DCC， BOC－氨基酸 2 HBr－F3CCOOH 肽的固相合成