河北医科大学药学院 易阿北后件太等 Spectrum 核磁共振在结构解析中的应用 ●● 史清文教 p22206.48.213:809 The problem the we want to solve by NMR e of ID I spe What”g [r止f H-NMR of Taxol(紫杉醇) 13 C NMR of Taxol®（紫杉醇@） 有多少C?表型 hi intr 有多少州？那些臭型？湘夏之间的关票了 天然药物化学室史清文教授河北医科大学药学院 天然药物化学室史清文教授 1 1 史清文 教授 Tel 86261270, QQ 46897262 核磁共振在结构解析中的应用 http://202.206.48.213:8091/ In the mid 1660’s, Sir Isaac Newton laid the foundation of spectroscopy by the discovery of the continuous spectrum of white light. The acceptance that light was comprised of seven colors led scientists on a journey to understand it’s nature. L I G H T Hundreds of years later, modern science has gained a greater comprehension of the mysteries of the world of light. Spectrum 1643-1727 3 What we “really” see What we want to “see” NMR The problem the we want to solve by NMR 4 1H 13C •Example of 1D : 1H spectra, 13C spectra of Codeine C18H21NO3, MW= 299.4 H3CO O HO N H H CH3 (紫杉醇®) 1H-NMR of Taxol® 有多少H？那些类型？相互之间的关系？ 13C NMR of 有多少C？那些类型？