Immunopathophysiology of Diabetes Dendritic cel APC CD2 Activated CD4+ TH1 CD4+T 到 Cell Cell THO】 DR3, L-12 DR4,,DQ8/insulin a,B,TCR IFN- CD40L peptide CD40 Macrophage/dendritic cell CD4+Cell FcR FasL (TH2) perforin CD40L CD8+CTL L-1,TNF,LT,NO,PGE-2 1L-4 CD40L B Cell ?anti-insulin, GAD ab anti- Mog B cell death ?Antibody mediated injury B islet cells L.Chess 2002 Activated TH1 CD4+ T Cell CD4+ Cell (TH2 ) CD4+ Cell (TH0 ) DR3, DR4,,DQ8/insulin peptide CD2 Macrophage/dendritic cell Fc R IFN- IL-12 CD40L CD40 ,, TCR IL-1, TNF, LT, NO, PGE-2 B Cell ?anti-insulin, GAD ab anti￾Mog IL-4 Immunopathophysiology of Diabetes ?Antibody mediated injury Dendritic cell/ APC CD40L IL-4 CD40L CD8+ CTL FasL perforin  cell death  islet cells L. Chess 2002