Changes in cell that are at the roots of cancer Genetic and epigenetic alterations. (Proto-oncogene, tumor suppressor gene, mutator gene) V Mutations Deletions Recombinations Transpositions Epigenetic alterations(DNA methylation, imprinting Acquisition of VirAL genetic materialChanges in cell that are at the roots of cancer Genetic and epigenetic alterations: (Proto-oncogene, tumor suppressor gene, mutator gene) Mutations Deletions Recombinations Transpositions Epigenetic alterations (DNA methylation, imprinting) Acquisition of VIRAL genetic material