Case 1 MRI ( Dec 15, 2015: Multiple space-occupying lesions in right frontal lobe and right thalamus region. T-spot(Dec 17, 2015 :+ Cryptococcus antigen(Dec 17, 2015) Lumber puncture(dec 17, 2015) Glucose 3.97mmol/ml, protein 875mg/LT, cells 106/LCase 1 • MRI (Dec 15, 2015): MulFple space-occupying lesions in right frontal lobe and right thalamus region. • T-spot (Dec 17, 2015): + • Cryptococcus anFgen (Dec 17, 2015): - • Lumber puncture(Dec 17, 2015): • Glucose 3.97mmol/ml, protein 875mg/L ↑, cells 10^6/L