2. Medicines: Industrial toxins, drugs are modified or degraded in the liver Hepatic cytotoxicity: Degeneration and necrosis of hepatic cells or synthesis of some proteins.如:异烟 肼,氟烷,醋氨酚,四环素、甲氨喋呤 Cholestasis: inhibit Na*-K ATP, fluidity of cell membrane如:氯丙嗪 1616 2. Medicines : Industrial toxins, drugs are modified or degraded in the liver ▪ Hepatic cytotoxicity: Degeneration and necrosis of hepatic cells or synthesis of some proteins. 如：异烟 肼，氟烷，醋氨酚，四环素、甲氨喋呤 ▪ Cholestasis: inhibit Na+ -K+ ATP, fluidity of cell membrane 如：氯丙嗪