安微医科大学国际教育学院教案与讲稿 【Pharmacokinetic Changes in the Elderly】 15 min Gastrointestinal Absorption none Drug Distribution Central Compartment Volume none or v Peripheral Compartment Volume Lipophilic Drugs ▲△ Hydrophilic Drugs Plasma Protein Binding Binding to Albumin v Binding to a 1-acid Glycoprotein none or▲ Drug Elimination Renal Elimination Hepatic Elimination Phase I Reactions CYP3A CYP1A2,2D6,2C9,2C19,2E1 none or Phase IⅡReactions Glucuronidation none Sulfation none Acetylation none Partial List of Drugs That Undergo Significant Renal Excretion in Humans] 10 min Amantadine(金刚烷胺)Aminoglycoside antibiotics(氨基苷类抗生素) Tetracycline(四环素)Quinidine(奎尼丁) Lithium（(锂盐)Digoxin(地高辛) Nitrofurantoin(呋喃妥因)Penicillin antibiotics(青霉素) Cimetidine(甲氰米胍)Furosemide(速尿，呋塞米) Sulfonamides(磺胺类)Phenobarbital(苯巴比妥) 【The Medication the General Principle】 10 min The efficacy and safety Dosage regimen Choice of Drugs Improve compliance Dosage choice Time choice of drug use 3安徽医科大学国际教育学院教案与讲稿 3 【Pharmacokinetic Changes in the Elderly】 15 min Gastrointestinal Absorption none Drug Distribution Central Compartment Volume none or ▼ Peripheral Compartment Volume Lipophilic Drugs ▲▲ Hydrophilic Drugs ▼▼ Plasma Protein Binding Binding to Albumin ▼ Binding to α1-acid Glycoprotein none or ▲ Drug Elimination Renal Elimination ▼▼ Hepatic Elimination Phase I Reactions CYP3A ▼ CYP1A2,2D6,2C9,2C19,2E1 none or ▼ Phase II Reactions Glucuronidation none Sulfation none Acetylation none 【Partial List of Drugs That Undergo Significant Renal Excretion in Humans】 10 min Amantadine（金刚烷胺）Aminoglycoside antibiotics（氨基苷类抗生素） Tetracycline（四环素）Quinidine（奎尼丁） Lithium（锂盐）Digoxin（地高辛） Nitrofurantoin（呋喃妥因）Penicillin antibiotics（青霉素） Cimetidine（甲氰米胍）Furosemide（速尿，呋塞米） Sulfonamides（磺胺类）Phenobarbital（苯巴比妥） 【The Medication the General Principle】 10 min The efficacy and safety Dosage regimen Choice of Drugs Improve compliance Dosage choice Time choice of drug use