Continuous(multiple)dose kinetics Number of Infusion: Elimination: Half-lives Fraction Fraction Remaining Accumulated(C/Css)(C/Css) 1 0.50 0.50 2345 0.75 0.25 0.88 0.12 0.94 0.06 0.97 0.03 Steady-state drug concentration The steady-state drug concentration depends on the drug dose administered per unit of time and also on the half-life of the drug.The figure shown next illustrates typical plasma concentration curves after drugs are given continuously or intermittently.If the dose is doubled,the steady-state concentration is also doubled.Likewise,if the half-life is doubled,the steady-state concentration is doubled.Continuous (multiple) dose kinetics • The steady‐state drug concentration depends on the drug dose administered per unit of time and also on the half‐life of the drug. The figure shown next illustrates typical plasma concentration curves after drugs are given continuously or intermittently. If the dose is doubled, the steady‐state concentration is also doubled. Likewise, if the half‐life is doubled, the steady‐state concentration is doubled. Steady‐state drug concentration