三、糖酵解途径的调节 1. The rate of glycolysis in mammals is mainly controlled at the step acted by phosphofructokinase-1(PFK-1)(Why?) (1) PFK-1 catalyzes an irreversible exergonic reaction, Which commits glucose to the glycolysis pathway (away from the pentose phosphate pathway) (2) PFK-1 is a complex tetrameric enzyme regulated by multiple intracellular signals (allosteric effectors): ATP, citrate being negative ones; AMP, ADP and fructose 2, 6 bisphosphate as positive ones三、糖酵解途径的调节 1. The rate of glycolysis in mammals is mainly controlled at the step acted by phosphofructokinase-1 (PFK-1) (Why?) (1) PFK-1 catalyzes an irreversible exergonic reaction, which commits glucose to the glycolysis pathway (away from the pentose phosphate pathway). (2)PFK-1 is a complex tetrameric enzyme regulated by multiple intracellular signals (allosteric effectors): ATP, citrate being negative ones; AMP, ADP and fructose 2,6- bisphosphate as positive ones