prototype artificial vessel structure poth mo m-dctamn. a. Describe the first events that will occur at the surface of a hydrophobic polymer like poly(tetrafluoroethylene)(structure shown below) when it is implanted as a vascular graft and how these events could lead to graft occlusion -(CF2-CF2)n (CF2-CF2)n- b. Would you choose a degradable or non-degradable polymer for the artificial vessel scaffolding? Explain your choice. (5 pt. s extra credit: describe what polymer in particular you would choose and motivate why you'd make that choice. C. One strategy that could be applied to this artificial vessel would be to implant the polymer and seek to have native endothelial cells and smooth muscle cells from the adjacent native vessels migrate into the polymer scaffold to recreate the native inner and outer cellular lining of the graft. Describe a strategy to modify the prototype scaffold in order to promote this process, and outline a preliminary experiment you could use to test the tility of your approach d. Inclusion of adhesion peptides in the inner surface of the artificial vessel could have both positive and negative effects on patentcy early after implantation-describe one positive and one negative outcome that could occur, depending on the choice of peptides utilized BE4623.962JPS1 20f2a. Describe the first events that will occur at the surface of a hydrophobic polymer like poly(tetrafluoroethylene) (structure shown below) when it is implanted as a vascular graft, and how these events could lead to graft occlusion. b. Would you choose a degradable or non-degradable polymer for the artificial vessel scaffolding? Explain your choice. (5 pt.s extra credit: describe what polymer in particular you would choose and motivate why you’d make that choice.) c. One strategy that could be applied to this artificial vessel would be to implant the polymer and seek to have native endothelial cells and smooth muscle cells from the adjacent native vessels migrate into the polymer scaffold to recreate the native inner and outer cellular lining of the graft. Describe a strategy to modify the ‘prototype’ scaffold in order to promote this process, and outline a preliminary experiment you could use to test the utility of your approach. d. Inclusion of adhesion peptides in the inner surface of the artificial vessel could have both positive and negative effects on patentcy early after implantation- describe one positive and one negative outcome that could occur, depending on the choice of peptides utilized. BE.462J/3.962J PS 1 2 of 2