Why use homology modeling? ° Ab Initio protein folding(“ randon” sampling) Y 100 aa, 3 conf /residue gives approximately 1048 different overall conformations Random sampling is NoT feasible, even if conformations can be sampled at picosecond (10-2 sec)rates. Do homology modelling insteadWhy use homology modeling? • Ab Initio protein folding (“random” sampling): ✓ 100 aa, 3 conf./residue gives approximately 1048 different overall conformations! • Random sampling is NOT feasible, even if conformations can be sampled at picosecond (10-12 sec) rates. • Do homology modelling instead