Primary complement deficiencies Conclusions Relatively uncommon diagnosed group of diseases Can be the underlying disease in autoimmunity and recurrent infections Laboratoty investigation of complement components is not easy,but C3 and C4 is normal available Most frequent is C2 deficiency Angioedema in C1 inhibitor deficiency appears n more generations in one family,differential diagnosis to allergy Primary complement deficiencies Conclusions • Relatively uncommon diagnosed group of diseases • Can be the underlying disease in autoimmunity and recurrent infections • Laboratoty investigation of complement components is not easy, but C3 and C4 is normal available • Most frequent is C2 deficiency • Angioedema in C1 inhibitor deficiency appears in more generations in one family, differential diagnosis to allergy