621 FILTER DRYER CRYSTALLIZER i CENTRIFUGE BLENDER BULK CONTAINER SPRAY DRYER Figure 2. Typical isolation process for a filter/dryer or spray dryer 8.0 SPRAY DRYING an be batch or production needs and the stability of the solutions to be spray dried. Because of reduced product manipulation, microbial and particulate burden can be educed. Normally there is a solution vessel, a filtration system with prefilters and sterile filters, a pressure vessel to feed the spray dryer at a controlled rate, spray dryer itself, and bulk containers The air used for product drying should be HEPA filtered. Whe esigned with silicone gaskets, the system will withstand sterilization peratures. The atomizing device can be either a spray nozzle or a high centrifugal device Spray dried products are typically temperature sensitive, therefore, air temperature should be controlled and as low as possible. Design of the atomizing device should ensure that product will not adhere to vessel walls Surface drying and depyrogenation can be done in a continuous operated tunnel or batch oven. The former method is preferred since it minimizes the potential of particulate contamination during loadingSterile Formulation 621 Figure 2. Typical isolation process for a filter/dryer or spray dryer 8.0 SPRAY DRYING Spray drying processes can be batch or continuous depending on production needs and the stability of the solutions to be spray dried. Because of reduced product manipulation, microbial and particulate burden can be reduced. Normally there is a solution vessel, a filtration system with prefilters and sterile filters, apressure vessel to feed the spray dryer at a controlled rate, the spray dryer itself, and bulk containers. The air used for product drying should be HEPA filtered. When designed with silicone gaskets, the system will withstand sterilization tem￾peratures. The atomizing device can be either a spray nozzle or a high speed centrifhgal device. Spray dried products are typically temperature sensitive, therefore, air temperature should be controlled and as low as possible. Design of the atomizing device should ensure that product will not adhere to vessel walls. Surface drying and depyrogenation can be done in a continuous operated tunnel or batch oven. The former method is preferred since it minimizes the potential of particulate contamination during loading