as the urine formation rapidly diminished, the wastes of protein metabolism and water, electrolytes accumulate in extracellular fluid. which is often characterized by 1. Azotemia Progressive elevation of NPN (Urea, creatinine, etc.) 2. Hyperkalemia May lead to ventricular fibrillation and cardiac arrest (No 1 cause of death) 3. Metabolic acidosis May depress CNs and heart, aggravate hyperkalemia 4. Retention of water and sodium Edema, hyponatremia and even water intoxication would occur if there is water and salts overload 3434 As the urine formation rapidly diminished, the wastes of protein metabolism and water, electrolytes accumulate in extracellular fluid, which is often characterized by: 4. Retention of water and sodium Edema, hyponatremia and even water intoxication would occur if there is water and salts overload 3. Metabolic acidosis May depress CNS and heart, aggravate hyperkalemia 2. Hyperkalemia May lead to ventricular fibrillation and cardiac arrest (No.1 cause of death) 1. Azotemia Progressive elevation of NPN (Urea, creatinine, etc.)