Sec 2 Preparation of alcohols(REV Functional group transformation: -Functional groups such as alkyl halides,carboxylic acids,esters,alkenes,aldehydes,ketones,and ethers can be transformed into alcohols. C-C bond formation Alcohols can be formed from epoxides,aldehydes, ketones,esters,and acid chlorides as a consequence of C-C bond formation with Grignard or organolithium reagents Reduction of Carbonyl -Reduction of aldehyde yields 1 alcohol. Reduction of ketone yields 2 alcohol. -Reagents:Sodium borohydride,NaBH4.Lithium aluminum hydride,LiAlH4:Raney nickelSec 2 Preparation of alcohols(REV) ❖Functional group transformation: ◼ Functional groups such as alkyl halides, carboxylic acids, esters, alkenes, aldehydes, ketones, and ethers can be transformed into alcohols. ❖C-C bond formation ◼ Alcohols can be formed from epoxides, aldehydes, ketones, esters, and acid chlorides as a consequence of C-C bond formation with Grignard or organolithium reagents ❖Reduction of Carbonyl ◼ Reduction of aldehyde yields 1ºalcohol. ◼ Reduction of ketone yields 2ºalcohol. ◼ Reagents:Sodium borohydride, NaBH4；Lithium aluminum hydride, LiAlH4；Raney nickel