Serotonin Neurons and the LHPA Axis .Studies have shown that the Serotonin(5-HT system and the Limbic Hypothalamic Pituitary-Adrenal (LHPA) axis are linked in a variety of ways. Hippocampus glucocorticoid and mineralocorticoid receptors SEROTONIN Pm UPTAKE SITES Dorsal Raphe PVN CBE Anterior Pituitary (POMC mRNA. Median Raphe PCIvC peptides) ACTH Glucocorticoids SEROTONIN SYSTEM Adrenal Cortex LHPA STRESS AXIS