图7-10体温调节自动控制示意图 思考题 1.外呼吸的呼吸商与细胞呼吸的呼吸商有何异同点及联系 2.能用测定甲状腺激素(T3,T4)的水平反映基础代谢率的高低吗? 3.试解释人精神高度紧张时能量代谢和体温的变化过程? 4.急性发热(如疟疾发作)时为何常表现出寒战,高热和大汗退烧的“三步曲”。 5.试述热环境和冷环境中,体温维持恒定的调节机制。 案例:患者蔡某,35岁,工人。2天前因淋浴受凉后出现体温升高,体温达40.2℃C,时有寒 颤,伴有流涕、咳嗽,诊断为普通感冒,经服用阿司匹林后患者大汘淋漓,随后体温下降至 37.8℃。 问题 1、请你解释为什么患者发热时有寒颤现象? 2、用退热药出汗后为什么患者的体温会下降? 3、体温的检测部位及其正常值如何?机体温度如何维持? 参考文献 Hilgemann DW. 1997. Cytoplasmic ATP-dependent regulation of ion transporters and hannels: mechanisms and messengers (Review). Annu Rev Physiol, 59: 193=220 2. Matsuzawa Y. 1997. Pathophysiology and molecular mechanisms of visceral fat yndrome: the japanese experience (Review). Diabetes Metab Rev, 13(1): 3-13 3. Weyer C, Walford RL, Harder IT. 2000. Energy metabolism after 2 year of energy restriction: the biosphere 2 experiment. Am j Clin Nutr, 72(4): 946-953 4. Jequier E, Tappy L. 1999. Regulation of body weight in humans(Review). Physiol Rev 79(2):451-80 5. Levine JA, Eberhardt NL, Jensen MD. 1999. Role of nonexercise activity therogenesis in resistance to fat gain in humans. Science, 283(5399): 212-214 6. Ganong WF.2001. Review of medical physiology.20thed.人民卫生出版社.271-306 7. Guyton AC, Hall je.2002. Textbook of medical physiology.10thed.北京医科大学出 版社.772-821 8. Nakazato M, Murakami N, Date Y, et al. 2001. A role for rgrelin in the central regulation of feeding. Nature, 409(6817): 194-198 9. Guyton AC, Hall JE. 2000. Textbook of Medical Physiology. 10th edition Philadelphia: WB saunders co 10. Lingappa VR, Farey K. 2000. Physiology medicine. New York, McGraw-Hill 11. Vander A, Sherman J, Luciano D. 2001. Human Physiology. &th edition, New York, Mc( 12. Shier D, Butler Lewis R. 1999. Hole s Human anatomy physiology. 8th edition New York, McGraw-Hill 13. Andrew Davies, Asa G H. Blakeley, Cecil Kidd. 2001. Human Physiology Philadelphia, WB saunders.图 7-10 体温调节自动控制示意图 思考题 1. 外呼吸的呼吸商与细胞呼吸的呼吸商有何异同点及联系？ 2. 能用测定甲状腺激素（T3，T4）的水平反映基础代谢率的高低吗？ 3. 试解释人精神高度紧张时能量代谢和体温的变化过程？ 4. 急性发热（如疟疾发作）时为何常表现出寒战，高热和大汗退烧的“三步曲”。 5. 试述热环境和冷环境中，体温维持恒定的调节机制。 例：患者蔡某，35 岁，工人。2 天前因淋浴受凉后出现体温升高，体温达 40.2℃，时有寒 ，伴有流涕、咳嗽，诊断为普通感冒，经服用阿司匹林后患者大汗淋漓，随后体温下降至 .8℃。 题： 为什么患者发热时有寒颤现象？ 出汗后为什么患者的体温会下降？ 测部位及其正常值如何？机体温度如何维持？ 考文献 Hilgemann DW. 1997.Cytoplasmic ATP-dependent regulation of ion transporters and channels: mechanisms Physiol, 59:193=220. Matsuzawa Y. 1997.Pathophysiology and molecular mechanisms of visceral fat ndrome: the Japanese experience(Review). Diabetes Metab Rev, 13(1):3-13 C,Walford RL, Harder IT.2000. Energy metabolism after 2 year of energy 2(4):946-953 ew). Physiol Rev, ivity e, 283(5399):212-214 . Ganong WF. 2001.Review of medical physiology.20th ed.人民卫生出版社.271-306 to M，Murakami N，Date Y，et al. 2001.A role for rgrelin in the central ion of feeding. Nature,409(6817):194～198. of Medical Physiology. 10th edition, New York, McGraw-Hill 1.Vander A, Sherman J, Luciano D. 2001. Human Physiology. 8th edition, New York, Graw-Hill Butler J, Lewis R. 1999. Hole's Human anatomy & physiology. 8th edition, y. 案 颤 37 问 1、请你解释 2、用退热药 3、体温的检 参 1. and messengers(Review). Annu Rev 2. sy 3. Weyer restriction:the biosphere 2 experiment.Am J Clin Nutr,7 4. Jequier E,Tappy L. 1999.Regulation of body weight in humans(Revi 79(2):451-80 5. Levine JA, Eberhardt NL, Jensen MD. 1999.Role of nonexercise act therogenesis in resistance to fat gain in humans .Scienc 6 7. Guyton AC,Hall JE. 2002.Textbook of medical physiology.10th ed.北京医科大学出 版社.772-821 8. Nakaza regulat 9.Guyton AC, Hall JE. 2000. Textbook Philadelphia: WB saunders Co. 10.Lingappa VR, Farey K. 2000. Physiology medicine. 1 Mc 12.Shier D, New York, McGraw-Hill 13. Andrew Davies, Asa G.H. Blakeley, Cecil Kidd. 2001.Human Physiolog Philadelphia, WB saunders. 6