Koch Postulates Robert Koch established the relationship between the tubercule bacillus and tuberculosis Developed the following three postulates o The pathogen occurs in every case of the disease in question associated with it characteristic pathologic clinical manifestations After being fully isolated from the body and repeatedly grown in pure culture, it can induce disease in a symptom-free host The pathogen can be recovered from the new host after symptoms appearKoch Postulates Koch Postulates – Robert Koch established the relationship between the tubercule bacillus and tuberculosis. – Developed the following three postulates z The pathogen occurs in every case of the disease in question associated with it characteristic pathologic clinical manifestations. z After being fully isolated from the body and repeatedly grown in pure culture, it can induce disease in a symptom-free host. z The pathogen can be recovered from the new host after symptoms appear