Risk Factors for Endometrial Hyperplasia and Carcinoma Factor Discussion Relative Risk Menopause 2. 4 times more likely for women undergoing menopause after age 52 than between 49 and 52 Unopposed Estrogen replacement without progestins; risk 4-8 estrogen increased with dosage and duration of use rapy Nulla Obesity 3 times more likely at 20-50 pounds overweight 3-10 10 times if more than 50 pound overweight; associated with aromatization of adrenally produced androstenedione estrone in fat cells Tamoxifen therapy 2-3 Diabetes mellitus 2003-10-27 Carcinoma of the endometrium2003-10-27 Carcinoma of the Endometrium 7