Acylation and sulfonylation O-N OO N N N H H2N HoN H2N 磺胺异口恶唑 磺胺嘧啶 磺胺地托辛 (Sulfafurazole) (Sulfadiazine) (Sulfadimethoxine) NH2 H2N NH 乙酰唑胺( Acetazolamide) 氢氯噻嗪( Hydrochlorothiazide) O N-C-NHCH CH2 SNH-C. NH Me 格列美脲( Glimepiride)S N O O O N H2N H S N O O H2N H N N S N O O H2N H N N O O 磺胺异 恶唑 (Sulfafurazole) 口 磺胺嘧啶 (Sulfadiazine) 磺胺地托辛 (Sulfadimethoxine) Acylation and Sulfonylation S NH2 O O N N N S O H S H2N O O S NH N O O H Cl 乙酰唑胺(Acetazolamide) 氢氯噻嗪(Hydrochlorothiazide) N O C O NHCH2CH2 S O O NH C NH O Me 格列美脲 (Glimepiride)