Symptomatology The usual presenting symptom of endometrial carcinoma is postmenopausal bleeding which carries a 10% risk of associated malignancy in the absence of hormone replacement therapy. Curettage,or endometrial sampling is mandatory Postmenopausal discharge from pyometra carries a 50% risk of associated malignancy. Pain may occur with pyometra or metastatic spread 2003-10-27 Carcinoma of the endometrium2003-10-27 Carcinoma of the Endometrium 10 Symptomatology The usual presenting symptom of endometrial carcinoma is postmenopausal bleeding which carries a 10％ risk of associated malignancy in the absence of hormone replacement therapy. Curettage，or endometrial sampling is mandatory. Postmenopausal discharge from pyometra carries a 50％ risk of associated malignancy. Pain may occur with pyometra or metastatic spread．