Bioavailability Bioavailability(F)is the fraction of the ME administered dose of a drug that reaches the systemic circulation in an active form An intravenously administered drug has 100% of bioavailability. A Bioavailabiity An oral drug has a fraction of bioavailability compared to the bioavailability of the same drug that is administered intravenously. An oral drug has a fraction of bioavailability compared to the bioavailability of the same drug that is administered intravenously. AUC Area Under Curve Te一 Continuous(multiple)dose kinetics Drug Accumulation:When a drug is administered continuously or repeatedly.the drug will accumulate until the amount of drug eliminated per unit time is equal to the amount of drug administered in the same amount of time.At this point,the drug will achieve a steady-state plasma concentration.Bioavailability Bioavailability (F) is the fraction of the administered dose of a drug that reaches the systemic circulation in an active form. An intravenously administered drug has 100% of bioavailability. An oral drug has a fraction of bioavailability compared to the bioavailability of the same drug that is administered intravenously. An oral drug has a fraction of bioavailability compared to the bioavailability of the same drug that is administered intravenously. AUC = Area Under Curve Continuous (multiple) dose kinetics