Organic Chemistry Organic and Biological Chemistry in Modern Medicine Coronary artery disease(CAD)is directly correlated with blood cholesterol levels 冠状动脉疾病 75%of blood cholesterol (1000 mg each day)is biosynthesized 、 他汀类药物 Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels他汀类降血脂药) 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)to mevalonate conversion 3-羟基-3甲基戊二酰辅酶A Crucial step in biosynthesis of cholesterol Atorvastatin(Lipitor)inactivates enzyme that catalyzes HMG- CoA to mevalonate conversion ■阿托伐他汀 Organic and Biological Chemistry in Modern Medicine ▪ Coronary artery disease (CAD) is directly correlated with blood cholesterol levels ▪ 75% of blood cholesterol (1000 mg each day) is biosynthesized ▪ Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels ▪ 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate conversion ▪ Crucial step in biosynthesis of cholesterol ▪ Atorvastatin (Lipitor) inactivates enzyme that catalyzes HMG￾CoA to mevalonate conversion ▪ 阿托伐他汀 Organic Chemistry 冠状动脉疾病 他汀类药物 3-羟基-3甲基戊二酰辅酶A 他汀类降血脂药）