Cell 04 015306090 69010 Stimulated Time(min E 口 2909 2 I HX RT transplanted [FFDG 吾西百 ingSAT AUtrans 。 ( trans 02 ● 《◆》 ce163,1360-1374, December3,2015@2015 Elsevier Inc.1363* * 0 30 60 90 120 0.2 0.4 0.6 0.8 1.0 1.2 RT transplanted Cold transplanted * 0 5 10 15 20 25 30 35 40 45 0.3 0.4 0.5 0.6 Time (min) Standardized uptake value (SUV) ingSAT (per fat pad) RT transplanted Cold transplanted * ** ** 0 50 100 150 0 50 100 150 Time (min) BAT ingSAT pgVAT perirenal VAT Soleus Quadriceps 0 10 20 30 40 *** *** *** *** n.s n.s 2[14C]DG uptake (basal) (ng / mg tissue / min) Glucose infusion rate (mmol / kg / min) 0 5 10 15 20 25 2[14C]DG uptake (glucose stimulated) (ng / mg tissue / min) BAT ingSAT pgVAT Soleus Quadriceps Brain 0 50 100 150 200 300 400 2[14C]DG uptake (hyperinsulinemic) (ng / mg tissue / min) ingSAT Soleus Quadriceps 0 5 10 15 RT transplanted Cold transplanted 2[14C]DG uptake (basal) (ng / mg tissue / min) *** Time (min) ITT - Glycemia (normalized) *** 0 30 60 90 120 15 0.2 0.4 0.6 0.8 1.0 1.2 RT Cold BAT ingSAT pgVAT Soleus Quadriceps A BC 0 10 20 30 50 60 70 80 90 100 Basal Stimulated RT Cold RT Cold RT Cold RT Cold D EF *** Rd (mmol / kg / min) G H I K 0 5 10 15 20 25 30 35 40 45 0.2 0.3 0.4 0.5 0.6 0.7 Time (min) Standardized uptake value (SUV) pgVAT (total) ** ** *** *** *** * * RT transplanted Cold transplanted J 0 5 10 15 20 25 30 35 40 45 0.1 0.2 0.3 0.4 0.5 Time (min) n.s Standardized uptake value (SUV) quadriceps L ** RT Cold ITT - Glycemia (normalized) Time (min) ** * ** * CT [ 18F] FDG RT transpl. ingSAT Cold transpl. pgVAT ingSAT pgVAT RT transpl. Cold transpl. (legend on next page) Cell 163, 1360–1374, December 3, 2015 ª2015 Elsevier Inc. 1363