BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 Bicontinuous microemulsions: interconnected microemulsion templates for mineralization Formed and then oil phase frozen to limit dynamic changes in liquid crystal nanochannel network during inorganic calcium phosphate crystallization Nanochannels formed with supersaturated solution; allowed to crystallize in surfactant encapsulated water channels Final structure composed of fibers with dimensions much larger than original nanochannels Growing calcium phosphate expands surfactant structure with time Frozen oil external Aqueo phase nanochannels Fig. 9.33 Micro-skeletal form of calcium phosphate prepared in bicontinuous microemulsions Scale bar, 1 um. Micellar biomineralization Growth of inorganic crystals from surface of micelles Model for microstructure development in one case: Ba CrO4-growth inside reverse micelles(water nanodroplets in oil phase) Cro4 6 nm Reverse micelle nanoreactors rmuoudasl menoyo her四u sulphosuccinate tld sufactant mmwe h. Irtetugeaton d the 如知可油出m间m出mm Lecture 11-Inorganic Biomaterials 10of12BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Lecture 11 – Inorganic Biomaterials 10 of 12 Bicontinuous microemulsions: interconnected microemulsion templates for mineralization: • Formed and then oil phase frozen to limit dynamic changes in liquid crystal nanochannel network during inorganic calcium phosphate crystallization • Nanochannels formed with supersaturated solution; allowed to crystallize in surfactant￾encapsulated water channels. • Final structure composed of fibers with dimensions much larger than original nanochannels: • Growing calcium phosphate expands surfactant structure with time Aqueous nanochannels Frozen oil external phase Micellar biomineralization • Growth of inorganic crystals from surface of micelles9 • Model for microstructure development in one case: Ba++CrO4—growth inside reverse micelles (water nanodroplets in oil phase) sulphosuccinate surfactant Reverse micelle nanoreactors Organic (oil) phase Ba++ CrO42- 6 nm