TISSUE ENGINEERINGREGEN MED Historical Perspective, Selected milestones 1980 Yannas: Collagen-GAG matrix for dermal regeneration(“ artificial skin”); Integra 1984 Wolter/Meyer: lst use of the term, TE; endothel like layer on PMma in the eye 1991 Cima/Vacanti/Langer: Chondrocytes in a PGa scaffold: the ear on the nude mouse 1993 Langer/Vacanti: Science paper on TE; cells in matrices for tissue formation in vitro: PgA 1994 Brittberg/Peterson: NEJM paper on human autologous chondrocyte implantation; CarticelTISSUE ENGINEERING/REGEN. MED. TISSUE ENGINEERING/REGEN. MED. Historical Perspective; Selected Milestones Historical Perspective; Selected Milestones 1980 Yannas: Collagen : Collagen -GAG matrix for dermal GAG matrix for dermal regeneration (“artificial skin”); Integra regeneration (“artificial skin”); Integra 1984 Wolter/Meyer: 1st use of the term, TE; : 1st use of the term, TE; endothel endothel . - like layer on PMMA in the eye like layer on PMMA in the eye 1991 Cima/Vacanti/Langer /Vacanti/Langer: Chondrocytes in a PGA : Chondrocytes in a PGA scaffold; the ear on the nude mouse scaffold; the ear on the nude mouse 1993 Langer/Vacanti Langer/Vacanti: Science paper on TE; cells in : Science paper on TE; cells in matrices for tissue formation matrices for tissue formation in vitro; in vitro; PGA 1994 Brittberg/Peterson Brittberg/Peterson: NEJM paper on human : NEJM paper on human autologous chondrocyte implantation; Carticel autologous chondrocyte implantation; Carticel