Thyroid hormone-Pharmacological mechanism o Mediated by activating its nuclear specificity T3 recepTors o T4 translated into T3 by deiodination and combined with the specificity T3 receptors, and regulate gene transcription, protein synthesis and play functions o Other factors lead to the decreasing in T3 receptorsThyroid hormone—Pharmacological mechanism Mediated by activating its nuclear specificity T3 receptors. T4 translated into T3 by deiodination and combined with the specificity T3 receptors, and regulate gene transcription, protein synthesis and play functions Other factors lead to the decreasing in T3 receptors