The sliding filament model A. Huxley Niedergerke, H. Huxley Hanson a quantitative model A Huxley 1957 See also textbooks by t. McMahon or J. Howard While in the bound state, the myosin head behaves as though loaded by linear springs with spring constant, K, and that it passes through the necessary biochemical processes including binding of ATP, Only the case of constant(time-invariant) relative sliding The muscle is assumed to be maximally activated throughout. Attachment and detachment is assumed to obey simple kinetics Effects of other elastic components in the muscle are ignored Myosin filament Myosin head Actin binding site Actin filament As the actin filament filament. the myosin head can bind to When it does, the springs are either stretched or at the bindi 10The sliding filament model A. Huxley & Niedergerke, H. Huxley & Hanson, Nature, 1954 A quantitative model A. Huxley 1957 See also textbooks by T. McMahon or J. Howard While in the bound state, the myosin head behaves as though loaded by linear springs with spring constant, k, and that it passes through the necessary biochemical processes including binding of ATP, ATP hydrolysis, and release of ADP. Only the case of constant (time-invariant) relative sliding velocity and force generation is considered. The muscle is assumed to be maximally activated throughout. Attachment and detachment is assumed to obey simple kinetics. Effects of other elastic components in the muscle are ignored. Myosin head Myosin filament Actin binding site Actin filament x� As the actin filament moves past the (fixed) myosin filament, the k myosin head can bind to + it at the red triangle. When it does, the springs k- are either stretched or compressed and a force kx acts at the binding x site. 10