BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 Lecture 6: Biodegradable Polymers for Tissue Engineering Last time: enzymatic degradation of solid polymers Engineering biological recognition of polymers Toda Designing polymers for tissue engineering Reading Tissue engineering-current challenges and expanding opportunities, L.G. Griffith and G Naughton, Science 295, 1009(2002) Overview of Biomaterials in Tissue Engineering Let's review the main approaches and applications in Tissue Engienering before getting into the details of materials for TE We will review the fundamental approaches that have been taken here and return to this topic later when we discuss integration of biological molecules in synthetic biomaterials TE scaffolds seek to provide a surrogate for natural ECM o Provide functions of native ecm o Create a space for new tissue development Deliver cells to site o Direct macroscopic size/shape of new tissue Tissue Engineering Approaches ·3 major approaches o In vitro tissue genesis in vivo application o In vivo tissue genesis→ in vivo application Schematic comparison of in vitro and in vivo tissue engineering approaches N VITRO SYNTHESIS N VITRO SYNTHESIS IN VIVO SYNTHESIS IN VIVO SYNTHESIS Lecture 6- Biodegradable Polymers in Tissue Engineering 1 of 5BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Lecture 6: Biodegradable Polymers for Tissue Engineering Last time: enzymatic degradation of solid polymers Engineering biological recognition of polymers Today: Designing polymers for tissue engineering Reading: ‘Tissue engineering- current challenges and expanding opportunities,’ L.G. Griffith and G. Naughton, Science 295, 1009 (2002) Overview of Biomaterials in Tissue Engineering Let’s review the main approaches and applications in Tissue Engienering before getting into the details of materials for TE We will review the fundamental approaches that have been taken here and return to this topic later when we discuss integration of biological molecules in synthetic biomaterials • TE scaffolds seek to provide a surrogate for natural ECM o Provide functions of native ECM o Create a space for new tissue development o Deliver cells to site o Direct macroscopic size/shape of new tissue Tissue Engineering Approaches • 3 major approaches o In vitro tissue genesis → in vivo application o In vivo tissue genesis → in vivo application Schematic comparison of in vitro and in vivo tissue engineering approaches1 : Skin: bone: Lecture 6 – Biodegradable Polymers in Tissue Engineering 1 of 5