Clinical manifestation and types Secondary osteoporosis Mndocrine and metabolic: hypogonadism hyperparathyroidism, hyperthyroidism, Cushing syndrome, acidosis Gaucher's disease Marrow diseases: myeloma, mastocytosis, thalassemia Medications: corticosteroids, dilantin, gonadotropin releasing hormone agonists, loop diuretics, methotrexate, thyroid, heparin, cyclosporin, depot-medroxyprogesterone acetate Malabsorption, Hepatic disease, others Hereditary skeletal diseases osteogenesis imperfecta, rickets, hypophosphatasia; t Primary osteoporosisClinical manifestation and types  Secondary osteoporosis： Mndocrine and metabolic: hypogonadism, hyperparathyroidism, hyperthyroidism, Cushing syndrome, acidosis, Gaucher's disease; Marrow diseases: myeloma, mastocytosis, thalassemia; Medications: corticosteroids, dilantin, gonadotropin releasing hormone agonists, loop diuretics, methotrexate, thyroid, heparin, cyclosporin, depot-medroxyprogesterone acetate; Malabsorption、Hepatic disease, others；  Hereditary skeletal diseases: osteogenesis imperfecta, rickets, hypophosphatasia;  Primary osteoporosis