Factors Determine viral Pathogenesis Viral virulence(eg cytopathic effect) Cellular and tissue damages as a result of host antiviral defenses against viruses [eg host defense mediated inflammation(localized or systemic ● Oncogenic factors Viral oncogene Insertion of viral dna in the host chromosomeFactors Determine Viral Pathogenesis z Viral virulence (eg. cytopathic effect) z Cellular and tissue damages as a result of host antiviral defenses against viruses [eg. host defense mediated inflammation (localized or systemic] inflammation (localized or systemic] z Oncogenic factors ¾ Viral oncogene Viral oncogene ¾ Insertion of viral DNA in the host chromosome