Great Targets for dominant acting oncogenes Secreted Growth factors, e.g. EGF. PDGF Specific Receptors for Growth factors e.g., RET, EGFR Cytoplasmic Nuclear G-proteins signa proteins Transcription kinases and transduction their targets actors, e.g., proteins Growth MYC JUN. FOS 9 RAS. ABL Factor (RB) GenesCytoplasmic signal transduction proteins Nuclear proteins Growth Factor Genes Great Targets for Dominant Acting Oncogenes Secreted Growth factors, e.g. EGF, PDGF Specific Receptors for Growth factors e.g., RET, EGFR G-proteins, kinases and their targets e.g., RAS, ABL, (RB) Transcription factors, e.g., MYC, JUN, FOS