Mechanisms of atrophy Shrinkage of cells due to increased catabolism of cell organelles and reduction of cytosol >Organelles and cytosol form autophagic vacuoles. which then fuse with primary lysosomes for enzymatic degradation;undigested lipids are stored as residual bodies,such as lipofuscin Loss of cells by apoptosis Mechanisms of atrophy Shrinkage of cells due to increased catabolism of cell organelles and reduction of cytosol  Organelles and cytosol form autophagic vacuoles, which then fuse with primary lysosomes for enzymatic degradation; undigested lipids are stored as residual bodies, such as lipofuscin Loss of cells by apoptosis