Soluble Inhibitors of Complement C1 inhibitor (C1 INH,C1 esterase inhibitor)- binds and inactivates C1->inhibition of Classical Pathway. Lack of C1 INH (hereditary angioneurotic edema)-spontaneous activation of complement and kinin systems,inflammation of the skin and critical organs. Symptoms are completely reversed by administration of C1 INH. Soluble Inhibitors of Complement C1 inhibitor (C1 INH, C1 esterase inhibitor) - binds and inactivates C1 → inhibition of Classical Pathway. Lack of C1 INH (hereditary angioneurotic edema) - spontaneous activation of complement and kinin systems, inflammation of the skin and critical organs. - Symptoms are completely reversed by administration of C1 INH