3. Get more families always a good idea 4. Determine phase in affected parents In each of the four families, we were uncertain about phase, and our LOd calculations embodied those uncertainties Family #4 HD SSR37 Phase HD 1: B two possible arrangements of alleles on mother's chromosomes Phase HD BD3. 4. Get more families — always a good idea Determine phase in affected parents In each of the four families, we were uncertain about phase, and our LOD calculations embodied those uncertainties. Family #4: + D Phase HD B 2: + B Phase HD D 1: HD SSR37 two possible arrangements of alleles on mother's chromosomes