Pathophysiology of SIRs Excessive uncontrolled inflammation over-responsiveness to inflmmation, siRS and CARS cytokines and other mediators released a Unstable circulation peripheral vascular resistance reduced early, and greatly clavated lately abnormal oxigen delivery(Ca-v02 decresed) Permanent high metabolism tissue oxigen consumption exceeds, bMR elavates substance use disturbedPathophysiology of SIRS ◼ Excessive uncontrolled inflmmation over-responsiveness to inflmmation,SIRS and CARS cytokines and other mediators released ◼ Unstable circulation peripheral vascular resistance reduced early，and greatly elavated lately abnormal oxigen delivery（Ca-vO2 decresed） ◼ Permanent high metabolism tissue oxigen consumption exceeds，BMR elavates substance use disturbed